雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Skin Changes in POEMS Syndrome Satoshi Kuwabara 1 1Department of Neurology, Graduate School of Medicine, Chiba University Keyword: POEMS症候群 , 浮腫 , 剛毛 , 色素沈着 , 血管腫 , 糸球体様血管腫 , POEMS syndrome , edema , hyperpigmentation , hypertrichosis , hemangioma , glomeruloid hemangioma pp.350-353
Published Date 2019/4/1
DOI https://doi.org/10.11477/mf.1416201274
  • Abstract
  • Look Inside
  • Reference

Abstract

Skin changes, including peripheral edema, hyperpigmentation, hypertrichosis, and hemangioma are frequent and early manifestations of POEMS (polyneuropathy, organomegaly, enndocrinopathy, M-protein, and skin changes) syndrome. Hemangiomata is presumably caused by overproduction of the vascular endothelial growth factor, and hypertrichosis results from the deposition of melanin; however, the pathogenesis of the skin symptoms are poorly understood. Nevertheless, recognition of the skin changes facilitates early diagnosis and treatment. Novel treatments, such as autoplantation, thalidomide/lenalidomide, and proteasome inhibitors have been availoble since 2000, and outcomes of the disorder have significantly improved. Appropriate understanding of the skin manifestations is clinically important for the early diagnosis of this intractable disorder.


Copyright © 2019, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

関連文献

もっと見る

文献を共有