BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 8 (August 2018)

Predictive Factors for Gastrointestinal Bleeding Following Hemorrhagic Stroke: A Hospital-Based Cohort Study Hirotaka Inoue 1 , Makiko Miyahara 1 , Yumi Funato 1 , Shota Ozaki 1 , Kensuke Kato 1 , Ryuichi Noda 1 , Shoji Yamaguchi 1 , Yuta Tamai 1 , Masato Inoue 1 , Koichiro Okamoto 1 , Tetsuo Hara 1 1Department of Neurosurgery, Center Hospital of the National Center for Global Health and Medicine Keyword: 出血性脳卒中 , 消化管出血 , 脳室穿破 , 抗凝固薬 , hemorrhagic stroke , gastrointestinal bleeding , ventricular rupture , anticoagulant medication pp.943-946
Published Date 2018/8/1
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Background and Purpose: Gastrointestinal bleeding is an important complication in the acute phase of hemorrhagic stroke. In this study, we aimed to identify the risk factors for gastrointestinal bleeding in patients with hemorrhagic stroke despite the administration of antiulcer drugs. Methods: We conducted a retrospective cohort study of our hemorrhagic stroke cases. We analyzed the background factors associated with gastrointestinal bleeding in the study population and their outcomes. Results: The study included 837 patients: 598 with intracerebral hemorrhages and 239 with subarachnoid hemorrhages. Among them, 22 patients developed gastrointestinal bleeding. Intraventricular hemorrhage (P=0.0019) and ongoing oral anticoagulant use (P=0.0177) were significantly associated with gastrointestinal bleeding. Gastrointestinal bleeding was significantly associated with severe disability at discharge (P=0.0333) and number of days of hospitalization (P=0.0190). Conclusions: The risk factors of poorly controlled gastrointestinal bleeding during the acute phase of hemorrhagic strokes were intraventricular hemorrhage and use of anticoagulant drugs. Patients with a high risk for gastrointestinal bleeding need to be identified and to be given effective prophylactic therapy.

(Received October 12, 2017; Accepted March 29, 2018; Published August 1, 2018)

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BRAIN and NERVE-神経研究の進歩
70巻8号 (2018年8月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院