Anti-MOG Antibody Associated Diseases Ichiro Nakashima 1,2 1Department of Neurology, Tohoku Medical and Pharmaceutical University Keyword: ミエリンオリゴデンドロサイト糖蛋白 , 脱髄疾患 , 多発性硬化症 , 視神経脊髄炎 , myelin oligodendrocyte glycoprotein , demyelinating disease , multiple sclerosis , neuromyelitis optica pp.1331-1336
Published Date 2017/11/1
DOI https://doi.org/10.11477/mf.1416200912
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The anti-MOG antibody is an autoantibody that induces inflammatory demyelinating lesions in the central nervous system in diseases such as optic neuritis, encephalitis, and myelitis. The recent development of a cell-based assay that can detect specific autoantibodies, which recognize conformational epitopes of membrane proteins, revealed the clinical features of diseases associated with the anti-MOG antibody. Because the disease spectrum of anti-MOG antibody-associated diseases is different from that of conventional demyelinating diseases, a new disease classification would be established in the near future.

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