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Environmental Risk Factors for Dementia Yoshitaka Tashiro 1,2 , Ayae Kinoshita 1,2 1Department of Human Health Sciences, Kyoto University Graduate School of Medicine 2SK project, Medical Innovation Center, Kyoto University Graduate School of Medicine Keyword: アルツハイマー病 , 認知症 , 危険因子 , 環境要因 , 糖尿病 , 高血圧症 , Alzheimer's disease , dementia , risk factor , environmental factors , diabetes , high blood pressure pp.837-847
Published Date 2016/7/1
DOI https://doi.org/10.11477/mf.1416200516
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Abstract

Owing to recent advancements in imaging techniques and biomarker research, the natural history of Alzheimer's disease (AD) has become clear from the very first preclinical stage. According to the study, more than 20 years before the onset of AD, Aβ starts to accumulate in the brain. This induces neurofibrillary tangle formation in the cerebral isocortex, leading to cognitive decline. If this process is suppressed, disease activity can be controlled. However, at this point, the best and most realistic way to deal with AD is to target the environmental factors that have been identified as risk factors by epidemiological studies.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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