BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 66, Issue 9 (September 2014)

Pathophysiology of Spasticity Yasuhiro Kagamihara 1 1Medical Corporation Taiheikai, Coral Clinic Keyword: 痙縮 , 上位運動ニューロン障害 , 伸張反射回路 , H反射 , 相反抑制 , spasticity , upper motor neuron disorders , stretch reflex pathway , H reflex , reciprocal inhibition pp.1019-1029
Published Date 2014/9/1
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Spasticity is characterized by abnormal increase in phasic and velocity-dependent response to muscle stretching, such as exaggerated tendon jerks and clonus. Clasp-knife phenomenon is often observed in the affected muscles. Spasticity is caused by either an excess input to the spinal cord or a disordered descending control of the spinal motor system including the myotatic reflex arc. The increased input due to hyperactivity of γ motor neurons has not been demonstrated in human subjects. The hyperactivity of excitatory interneurons and decreased function of the inhibitory system interneurons in the spinal cord as well as the uncoupling of the inhibitory system from the central system are believed to be involved in spasticity; however, the underlying pathology may differ based on the lesion site and the time elapsed since loss of reciprocal inhibition.

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BRAIN and NERVE-神経研究の進歩
66巻9号 (2014年9月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院