Autonomic Features in Parkinson Disease Toshimasa Yamamoto 1 , Naotoshi Tamura 2 1Department of Neurology,Faculty of Medicine,Saitama Medical University 2Saitama Medical University College Keyword: Parkinson disease , autonomic dysfunction , gastrointestinal dysfunction , sweating dysfunction , cardiovascular dysfunction pp.394-402
Published Date 2012/4/1
DOI https://doi.org/10.11477/mf.1416101168
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 Nonmotor symptoms such as autonomic and neuropsychiatric dysfunctions, are commonly seen in Parkinson disease (PD). Recent studies have shown that PD is accompanied by cardiac sympathetic denervation and constipation even in the early stage. Neuropathological studies confirmed changes in the cardiac sympathetic nerves and the gastrointestinal tract. These findings suggest that PD neuropathology may occur first in the peripheral autonomic pathways and extend to the central autonomic pathways, in agreement with the "Braak theory".

 This article will reviews the symptoms and pathophysiology of gastrointestinal dysfunction,urinary disturbance,sexual dysfunction,sweating dysfunction,pupillary autonomic dysfunction,and orthostatic and postprandial hypotension in PD patients,and discuss to organ selectiveness in autonomic dysfunction in PD.

Copyright © 2012, Igaku-Shoin Ltd. All rights reserved.


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