Cognitive Impairment in Patients with Parkinson Disease Nobuhito Abe 1 , Etsuro Mori 2 1Kokoro Research Center,Kyoto University 2Department of Behavioral Neurology and Cognitive Neuroscience,Tohoku University Graduate School of Medicine Keyword: cognitive impairment , dopamine , executive function , frontostriatal circuitry , Parkinson disease pp.321-331
Published Date 2012/4/1
DOI https://doi.org/10.11477/mf.1416101161
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 Parkinson disease is a progressive neurodegenerative disorder resulting in motor symptoms and cognitive deficits. Neuropsychological studies have suggested that patients with Parkinson disease exhibit a broad range of cognitive deficits even in the early stages of the disease. In this review,we discuss the neuropsychological evidence for cognitive impairment in patients with Parkinson disease,outlining the different domains of cognitive disturbance. First,we review previous findings on executive dysfunction,which is associated with a disruption in frontostriatal circuitry mainly driven by dopaminergic dysmodulation. Executive dysfunction is the core symptom in the cognitive deficits in Parkinson disease. Second,we focus on impairment in different domains of memory function,such as short-term and long-term memory. Third,we discuss the pattern of cognitive deficits in visuospatial ability,ranging from basic perceptual processes to rather complex motor skills. Next,we summarize the profile of cognitive deficits in language,although previous findings are mixed and hence this topic is relatively controversial. Finally,we introduce several recent findings on social cognitive deficits,which is a new area of research that has emerged in the past decade. We also discuss the possible neural mechanisms underlying each domain of cognitive deficits in patients with Parkinson disease.

Copyright © 2012, Igaku-Shoin Ltd. All rights reserved.


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