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A 62-year-old Woman Presenting with Progressive Nonfluent Aphasia,Apraxia of Eyelid Opening,Supranuclear Gaze Palsy,and Asymmetric Rigidity Keisuke Suzuki 1 , Toshiki Nakamura 2 , Naoki Izawa 1 , Kenichi Hashimoto 1 , Keita Ouchi 1 , Saiko Aiba 1 , Koichi Hirata 1 1Department of Neurology,Dokkyo Medical University 2Department of Neurology,Rehabilitation Amakusa Hospital Keyword: progressive nonfluent aphasia , corticobasal degeneration , progressive supranuclear palsy , apraxia of eyelid opening pp.884-889
Published Date 2011/8/1
DOI https://doi.org/10.11477/mf.1416100980
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Abstract

 A 62-year-old woman presented with difficulty in speaking and difficulty in opening her eyes. A neurological examination revealed progressive nonfluent aphasia (PNFA), apraxia of eyelid opening, supranuclear vertical gaze palsy, and mild asymmetric rigidity. The diagnosis was difficult to establish because of unusual clinical features, and progressive supranuclear palsy (PSP) was considered. The results from recent studies suggest a positive association between PNFA and a diagnosis of corticobasal degeneration (CBD) or PSP, even in mild parkinsonism cases. The overlapping clinical, genetic, and pathological features of CBD and PSP have also been recently recognized. However, in Japan, there have been few reports evaluating the clinical features of CBD or PSP accompanied by primary progressive aphasia. We report the case of our patient and compare the clinical features of our patient with those of Japanese patients with CBD or PSP accompanied by primary progressive aphasia; moreover we discuss clues that can lead to the correct clinical diagnosis of patients with primary progressive aphasia and parkinsonism comorbidities.

(Received: December 6,2010,Accepted: February 14,2011)


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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