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Particle Radiotherapy for Malignant Gliomas Tetsuya Yamamoto 1 , Koji Tsuboi 1 1Graduate School of Comprehensive Human Science,University of Tsukuba Keyword: glioma , radiation , proton , boron neutron capture therapy (BNCT) pp.855-866
Published Date 2009/7/1
DOI https://doi.org/10.11477/mf.1416100528
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Abstract

 Particle radiations using protons or carbons,and boron neutron capture therapy are emerging as a therapeutic modality for malignant gliomas. Some non-randomized prospective studies found favorable results; however,the advantageous method of advantage of conformal radiation using protons or carbon ions and tumor cell-selective radiation using boron neutron capture therapy have not been confirmed. In a recent clinical trial involving 20 newly diagnosed glioblastomas at the Proton Medical Research Center at Tsukuba,the median overall survival time and the 1- and 2-year survival rates were 21.6 months,71.1% and 45.3%,respectively. In the clinical trial of boron neutron capture therapy of 15 newly diagnosed glioblastomas at Tsukuba,the median overall survival time and the 1- and 2-year survival rates were 25.7 month,80.0% and 53.3%,respectively. The rationale,history,and clinical results of particle radiotherapy for glioblastoma were also discussed.


Copyright © 2009, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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