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71歳の女性が多発性骨髄腫で,42歳の女性が自己免疫性溶血性貧血でシクロフォスファミド内服中に血尿と膀胱タンポナーデで入院した。生理食塩水での膀胱灌流やprostaglan-dinF2α膀注では血尿の改善は一時的であったが,高圧酸素療法を行うと血尿は完全に消失した。高圧酸素療法は簡便で,ほとんど副作用はなく,患者の苦痛という面からも非常に優れた治療と考えられた。
A 71-year old woman with multiple myeloma and a 42-year old woman with hemolytic anemia, taking cyclo-phosphamide, were admitted because of macrohematur-ia and bladder tamponade. Bladder irrigation and intravesical prostaglandin F2-alpha instillation were per-formed to control hemorrhage, however, their effect were transient. The treatment of hyperbaric oxygen was then tried, which completely relieved hematuria. To stop bladder bleeding induced by cyclophosphamide adminis-tration, hyperbaric oxygen therapy could be both safer and easier than previous methods.
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