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Clinical characteristics of non-metastatic prostate cancer treated with androgen deprivation therapy in elderly patients aged ≧ 80 years Nobuyuki Sekita 1 , Hiroaki Sato 1 , Hiroyoshi Kouno 1 , Masaaki Fujimura 1 , Nobuyoshi Takeuchi 2 , Rika Nishikawa 2 , Kazuo Mikami 1 Keyword: 内分泌療法 , 高齢者 , 前立腺癌 pp.265-270
Published Date 2016/3/20
DOI https://doi.org/10.11477/mf.1413205567
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Abstract

Between January 2000 and December 2010, 82 patients, aged ≥ 80 years, with localized prostate carcinoma, who were treated with androgen deprivation therapy were retrospectively subjected to evaluation of survival rate and multivariate regression analysis. Comorbidities were measured from medical records using the Charlson comorbidity index (CCI). The mean age of the patients was 83 years, and the median pretreatment PSA level was 18.2ng/mL. The overall and cancer-specific survival rates were 78% and 93%, respectively. Cancer-specific survival rates were significantly lower in patients with Gleason's sums ≥ 8 than in patients with sums < 8. Between the two CCI score groups, overall survival rates differed significantly. During multivariate analysis, CCI ≥ 1 was an independent factor for poor prognosis. Among elderly patients with localized cancer, the probability of cancer-specific death was very low regardless of PSA levels and clinical T stages. Patients with one or more CCI were at high risk of death by other causes. Therefore, the diagnosis and treatment of prostate cancer in men aged ≥ 80 years should be carefully performed considering not only the potential risk of cancer malignancy but also the individual health conditions and comorbidities (Rinsho Hinyokika 70 : 265-270, 2016).


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電子版ISSN 1882-1332 印刷版ISSN 0385-2393 医学書院

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