副腎黒色腺腫によるクッシング症候群の2例

FUNCTIONAL BLACK ADENOMA IN CUSHING'S SYNDROME: REPORT OF TWO CASES

緒言

　副腎の黒色腺腫が剖検で見つかることは稀ではないが，これらのほとんどが無症候性のものであり，内分泌症状を惹起したものは極めて稀である。今回私たちはクッシング症候群を呈した副腎黒色腺腫を2例経験したので症例報告すると同時に若干の文献的考察を加えた。

Pigmented nonfunctional adenomas of the adrenal gland are frequently found at autopsy but functional black adenomas are rare. We reported two cases of functioning black adenoma of the adrenal gland that produced the characteristic clinical and laboratory findings of Cushing's syndrome.

Both the electromicroscopical findings and positive stains with PAS, oil red O, schmorl identified the pigmented granules as lipofuscin, although the source of the lipofuscin and mechanisms underlying the increase of this material is unknown.