細菌性ショックに皮膚壊死を伴つた1例—セファロチン静注に起因すると思われる

SKIN NECROSIS IN PATIENT WITH BACTERIAL SHOCK PROBABLY DUE TO CEPHALOTHIN INJECTION

緒言

　尿管結石を基礎疾患として，大腸菌による細菌性ショック患者に，セファロスポリン系の抗生物質であるセファロチンを静注したところ，著しい局所の疼痛を訴え，静注部位3ヵ所がいずれも壊死に陥つた症例を報告する。

A 61-year-old female with right ureteral stone went into shock 36 hours after admission. Cepha-lothin was injected intravenously for suspected bacterial shock but skin necrosis developed at the 3 injected site after sever pain. Skin transplantation was performed after recovery from bacteriemia. E. coli was isolated by culture of patients blood.

Necrosis of the skin can occur only from bacterial shock secondary to damage of the endothel cell of the blood vessel. Phlebitis secondary to intravenous administration of cephalothin has been reported.