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Clinical significance of human chorionic gonadotropin(hCG)and βhCG in testicular cacer Akitoshi Takizawa 1 , Takeshi Miura 1 , Kiyoshi Fujinami 1 , Yutaka Osada 1 1Department of Urology,Kanagawa Cancer Center,Yokohama,Japan pp.405-409
Published Date 2005/5/20
DOI https://doi.org/10.11477/mf.1413100336
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The use of serum human chorionic gonadotropin β-subunit(βhCG)as a specific marker of testicular cancer is controversial. Recently,a monoclonal immunoradiometric assay for hCG showed no cross-reactivity with luteinizing hormone. Twenty-five patients with testicular cancer(four with seminomatous germ cell tumors[SGCTs]and twenty-one with non-seminomatous germ cell tumors[NSGCTs])who were referred to our hospital over the last 10 years were assessed using serum hCG and βhCG assays. Serum hCG and βhCG were detected in 75% and 100% of the patients with SGCTs and in 95.2% and 90.5% of the patients with NSGCTs,respectively. Thus,the serum hCG and βhCG levels were highly correlated(r=0.90,p<0.001)in patients with NSGCTs,but not correlated in the patients with SGCTs. Three patients with NSGCTs exhibited marker recurrences seven times in total and only hCG was elevated in four of these instances,while hCG and βhCG were simultaneously elevated in the remaining three instances. These results suggested that βhCG is more useful as a marker of SGCT,while hCG is more useful as a marker of NSGCT. Simultaneous determination of both markers may be more helpful for the management of testicular cancer.


Copyright © 2005, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1332 印刷版ISSN 0385-2393 医学書院

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