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EOSINOPHILIC GRANULOMA OF BONE WITH SKIN MANIFESTATION Masaru WASHIO 1 , Masaaki MOROHASHI 1 , Masao NAGABA 2 1Department of Dermatology, Niigata University School of Medicine 2Department of Otolaryngology, Niigata University School of Medicine pp.599-610
Published Date 1972/7/1
DOI https://doi.org/10.11477/mf.1412201010
  • Abstract
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A case of this disease in the left temporal bone in a 2-year-and-3-month-old boy with the disseminated papules after the extirpation of the lesion was reported.

Histologic pictures of the eruption resembled those of Letterer-Siwe's disease and were different from the findings of the bone.

Electron microscopic findings of the histiocytic cells of the eruption showed almost the same character-istics as those in Hand-Schuller-Christian's and Letterer-Siwe's disease. These results from histologic and EM studies strongly suggested that these three diseases belonged to the same disease entity.

When the eosinophilic granuloma is accompanied with the disseminated papules, it should be regarded as a sign of the progression and exacerbation. In such an instance the chemotherapy including vinblastin sulfate and adrenocortical steroid therapy should be tried.


Copyright © 1972, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1324 印刷版ISSN 0021-4973 医学書院

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