皮膚化膿巣由来のブドウ球菌のvirulenceに関する研究

STUDIES ON VIRULENCE, PHAGE TYPING AND SENSITIVITY TEST OF STAPHYLOCOCCI FROM PYODERMAS

はじめに

　皮膚由来のブドウ球菌（以下ブ菌と略す）は，病原菌としてのみならず常在菌としての性質についてもすでに多くの実験的研究が報告されている。

　ブ菌の病原性に関してはコアグラーゼ産生能，マンニット分解能の有無によつてそれら酵素産生の多いものを病原性ブ菌と定めているが，非病原菌といわれる表皮ブ菌がしばしば病巣より分離されることが臨床的にもみられ，この分類にも問題がもたれてきている。

Bacteriologic studies, especially the change of strains, the coagulase test, and the phage typing on the staphylococci isolated from impetigo and furuncles in patients at the Department of Dermatology, Jikei Medical School in 1967 were performed. The results were as follows :

1. There was nothing new on the sensitivities of staphylococci of various phage types to antibiotics. No evidence for the alteration of strains of staphylococci was proved.

2. Rather frequently, coagulase negative cocci which have been regarded as non-pathogenic organisms, were cultivated from lesions. The virulence of the coagulase negative cocci to mice was proved to be completely negative, while that of coagulase positive cocci was positive.

3. When forty strains of staphylococci which were susceptible to phage 71 were mixed with each other, definitely bacteriolytic areas were demonstrated. It is probable that further detailed classification of phage 71 type staphylococci by prophage may be performed.