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はじめに
さきに土井ら1)は舌,口腔,食道,咽頭部,外陰,肛門などに系統的びらん形成と口蓋扁桃部に扁平上皮癌を伴なつた尋常性天疱瘡の剖検例を報告し,さらに本邦剖検例を集計検討して各種内分泌器にみられた変化を2次的なものとしている。
著者らも尋常性天疱瘡の1例を経験し,螢光抗体法によつて表皮細胞間物質に対する抗体を検索し得,さらに剖検する機会に恵まれたので報告する。
A 37-year-old housewife first noticed injected conjunctivas of both eyes and slomatitis at the beginning of November, 1965. In February 1966, erythemato-vesicular and bullous lesions, and crusts covered the entire body surface. Histogic picture from the vesicle was typical of pemphi-gus vulgaris.
Adrenocortical hormones were effective, but the disease in the patient was accompanied by herpes zoster, bilateral bronchial pneumonia and thrombophlebitis. She died of general weakness on Octover 10, 1967.
The serum protein level was low and the serum albumin decreased, the α1- and α2-globulin increased and indirect coombs' test positive. The antibody in the serum against an intercellular substance in the epidermis was proved positive by the indirect fluorescent antibody technique.
Autopsy revealed starvation atrophy of all organs except the hypophysis and thyroid, brown atrophy of the heart and lever, bilateral bronchial pneumonia and multiple gastric erosions.
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