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LINEAR ATROPHY ON THE BREASTS : WITH REFERENCE TO THE PATHOGENESIS Natsue SHIMIZU 1 , Itsuro MATSUO 1 , Hideo NAKAYAMA 1 1Department of Dermatalogy, Keio University School of Medicine pp.1067-1071
Published Date 1967/10/1
DOI https://doi.org/10.11477/mf.1412200225
  • Abstract
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Biochemical and histopathological studies of linear atrophy on the breasts in a 20-year-old unmarried woman were performed.

Increased urinary excretion of 17-ketosteroids and of 17-hydroxycorticoids and a slight enlargement of the left adrenal were proved, although she had no clinical signs and symptoms suggesting Cushing's disease.

Pregnancy, obesity, severe infectious disease or diabetes mellitus were not found in her past history or in physical examinations and laboratory tests.

These clinical findings and laboratory results suggest the following three pathomechanisms in this case.

1) It is due to an oligosymptomatic Cushing's syndrome (Hauser) which may develop into typical Cushing's disease.

2) She has had an episode of transitional adrenocortical hyperf unction. Furthermore, topical application of the triamcinolone ointment might have accelerated the development of the skin manifestation.

3) She has had an episode of a high increase in the adrenocortical function which formed the striae, but now the adrenal cortex is functioning normally.

As a conclusion the third mechanism may be the most possible factor and the second acted as an accelerating factor.


Copyright © 1967, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1324 印刷版ISSN 0021-4973 医学書院

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