Pseudoglandular Squamous Cell Carcinomaの1例

A CASE OF PSEUDOGLANDULAR SQUAMOUS CELL CARCINOMA

I．はじめに

　原発性皮膚癌の中に，特異な組織像を呈する偽腺様有棘細胞癌（pseudoglandular squamouscell carcinoma）があり，現在，一般に有棘細胞癌の1型とされている。最近経験した本症の1例を報告し，簡単に文献的考察を行ないたい。

A 62-year-old man noticed a rice-sized papule on the back of the nose, which enlarged gradually and became a domeshaped, hard, dark red nodule, 3×2.8cm. in size, with shallow ulce-ration in its center. The ulcer was uneven, dirty, yellowish-red, 1.5cm. in diameter, and studded with horny masses and blood crusts. The regional lymph nodes were not palpable.

Histologic specimens from the border of the ulcer showed pronounced proliferation of squamous cells accompanied by horn pearls. The specimen from the ulcer revealed an alveolar structure of proliferating anaplastic keratinocytes partly with luminal or tubular figures inva-ding deep into the dermis. Some of the tumor cells showed individual cell keratinization, for-mation of horn pearls, mitotic figure, desquamation or acantholysis. Three months after radiation therapy composed of 3,400r of deep x-ray and 4,200r of Co⁶⁰, the tumor disappeared and replaced by a scar. A review was performed about 85 cases reported from abrord and 7 cases from Japan including the author's case after 1947.