神経線維腫の混在した喉頭顆粒細胞腫の1症例

Granular Cell Tumor of the Larynx:A Case Report

　はじめに

　顆粒細胞腫（granular cell tumor：以下，GCTと略す）は，1926年Abrikossoff^1）により記載されて以来，種々の臓器で報告がみられる良性軟部腫瘍であるが，その組織由来については未だ定説をみない。今回われわれは，喉頭に発生し，その病理組織学的および免疫組織学的所見から末梢神経由来であることが強く示唆された神経線維腫との移行が認められたGCTの1症例を経験したので，若干の文献的考察を加え報告する。

A 55-year-old male presented with granular cell tumor (GCT) of the larynx.

Endoscopic examination revealed a whitish tumor in the right arytenoid of the larynx, and the tumor was excised by laryngomicrosurgery.

Histologically, the tumor cells were mainly com-posed of abundant granular eosinophilic cytoplasm, and small hyperchromatic nuclei without encapsula-tion. These lesions showed immunoactivity for S100, vimentin, and KP-1.

In one of the specimens, histological finding revealed the “neurofibroma” adjacent to the lesions of GCT, and it expressed S100, neurofilament pro-tein, synaptofidin, chromogranin, GFAP, and vimetin.

These findings suggested GCT was derived from the neurofibroma and supported the histogenesis that GCT has its origin from peripheral neural tissue.