当科で経験した頭頸部原発小細胞癌の2例

Two cases of small cell carcinoma of the head and neck

はじめに

　小細胞癌は肺以外の組織にも発生することが知られているが，頭頸部に発生するのは稀である。しかし，肺小細胞癌と同様に悪性度が高いため，適切な治療方針の決定，早期治療開始が重要である。今回われわれは，頭頸部原発の小細胞癌を2例経験したため，文献的考察をふまえて報告する。

　　Small cell carcinoma is known to occur in tissues other than the lungs but rarely in the head and neck. We report two cases of small cell carcinoma of the head and neck.

　A woman in her 70 s was diagnosed with a tumor of the nasolacrimal duct on magnetic resonance imaging.

　The tumor was diagnosed as a small cell carcinoma based on biopsy findings, and distant or lymph node metastases were not detected.

　A man in his 70 s was diagnosed with a tumor involving the cheek on ultrasonography.

　The tumor was diagnosed as a small cell carcinoma based on biopsy findings, and distant or lymph node metastases were not detected.

　Both patients were administered chemoradiotherapy using CDDP（80 mg/m²）and VP-16（100 mg/m²）, which resulted in remission within 2 months.

　Although no established treatment is available for small cell carcinoma of the head and neck, treatment is usually administered based on the guidelines used for management of small cell lung cancer.