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Modulation of Peripheral Blood Lymphocyte Subsets in Advanced Head and Neck Carcinoma Cases, using Two Color Flow Cytometric Analysis Mamoru Tsukuda 1 1Department of Head and Neck Surgery, Kanagawa Cancer Center pp.763-768
Published Date 1988/9/20
DOI https://doi.org/10.11477/mf.1411200222
  • Abstract
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The peripheral blood lymphocyte subsets in advanced cases with head and neck carcinoma were analyzed by two color flow cytometry.

(1) The rate of each lymphocyte subset, specu-lated in two color analysis, correlated well with those of matched population, which was analyzed with a single color method.

(2) The ratio of Leu 11c+・Leu 7- NK cells, which possesses the strongest NK activity in NK subpopulation, decreased in carcinoma cases.

(3) On analyses of T cell subsets, the rate of suppressor T cells (Leu 2a+・Leu 15+) elevated, and that of cytotoxic T cell (Leu 2a+ ・Leu 15-) adversely declined in cancer cases. Otherwise, the ratio of suppressor inducer T cells (Leu 3a+・Leu 8+) decreased, and that of helper T cells (Leu 3 a+・Leu 8-) increased in these cases.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1316 印刷版ISSN 0914-3491 医学書院

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