Lymphocyte subsets of human conjunctival follicles Yoshitsugu Tagawa 1 , Monabe Saito 1 , Takashi Kosaka 1 , Tsutomu Takeuchi 1 , Hidehiko Matsuda 1 , Tsuyoshi Takami 2 , Kokichi Kikuchi 2 1Dept. of Ophthalmol, Hokkaido Univ Sch of Med 2Dept of Pathol, Sapporo Med Coll pp.239-242
Published Date 1986/3/15
DOI https://doi.org/10.11477/mf.1410209643
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We evaluated lymphocyte subsets in conjunctival follicles obtained by biopsy from 5 patients with fol-licular conjunctivitis. We employed the immunoper-oxidsase (ABC) method using monoclonal antibodies against various human leucocyte antigens.

In the center of follicles, B cells predominated bearing surface IgM and IgD. T cells were distributed predomi-nantly in the parafollicular area. Helper/inducer T cells were much more numerous than suppressor/cytotoxic T cells. Numerous plasma cells were distributed in the subepithelial space of the follicles. IgA plasma cells were dominant types. Secretory component of secretory IgA was present in all the epithelial cells of the conjun-ctiva. Langerhans cells and suppressor/cytotoxic T cells were the chief immunocompetent cells in the epithelium. The findings show that the lymphocyte composition in the follicles are similar to that in the Peyer's patches and solitary lymphoid follicles in small intestine in humans. Conjunctival follicles are therefore the site of differentiation of B cells into antibody producing cells, particularly of IgA. Conjunctival follicles seem to play an important role in the secretory immune system of human conjunctiva.

Rinsho Ganka (Jpn J Clin Ophthalmol) 40(3) : 239-242, 1986

Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.


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