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A case of hypertensive retinopathy secondary to renal failure and treatment with epoetin beta obtained by gene manipulation Nanae Kunito 1 , Isao Okamoto 1 , Masao Nagata 1 , Akihiko Tamai 1 , Kazuhiko Adachi 2 , Kenichi Ozaki 2 1Dept of Ophthalmol, Fac of Med Tottori Univ 2Ozaki Surg Clinic pp.285-289
Published Date 1992/3/15
DOI https://doi.org/10.11477/mf.1410901035
  • Abstract
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Uremic anemia is generally ascribed to inade-quate secretion of erythropoietin, EPO. Human EPO has been gene-coded and cloned in cultured mammalian cells. Recombinant human EPO, rhEPO, or genetically recombined epoetin beta, became available for treatment of renal anemia. This agent is claimed to induce remarkable amelio-ration of renal anemia without serious side effects.

A 31-year-old had been diagnosed as renal failure 15 years before. He had been under hemodialysis for the past 29 months. Bilateral hypertensive retinopathy developed presumably caused by sys-temic hypertension and rhEPO. Fundus findings improved soon after discontinuation of treatment with rhEPO. The visual acuity was no serieously impaired throughout the course. This case illus-trates the possible deleterious effect to the eye in patients undergoing hemodialysis with additional rhEPO therapy.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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