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Penetration of l-ofloxacin (DR-3355) into the lacrimal fluid Takao Tomii 1 , Masamichi Fukuda 1 , Kazuyuki Sasaki 1 1Dept of Ophthalmol, Kanazawa Med Univ pp.1607-1610
Published Date 1991/9/15
DOI https://doi.org/10.11477/mf.1410900829
  • Abstract
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We quantitated the tear fluid level of l-oflox-acin, a new quinolone antimicrobial agent, after peroral administration of 100 mg in 13 healthy volunteers aged from 24 to 39 years, average 32 years. When tear fluid was collected from the meniscus of the precorneal film, the peak concen-tration after 2 hours averaged 0.61±0.25 μg/ml. When tear fluid was collected from the cul-de-sacafter instillation of 20μl of physiological saline, the peak concentration after 2 hours averaged 0.92± 0.67 μl/ml. Values by the two methods were well correlated. Drug levels could be detected for up to 8 hours by the first method and up to 12 hours by the second. The concentration of l-ofloxacin in the tear fluid was similar to other quinolone antimi-crobial agents.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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