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Laboratory and clinical studies of cefmenoxime ophthalmic solution Takao Tomii 1 , Masamichi Fukuda 1 , Noriko Watanabe 2 , Kazuyuki Sasaki 3 , Chizuko Kawasaki 1 1Department of Ophthalmology, Kanazawa Medical University 2Dept. of Ophthalmol., Fukui Hosp. 3Dept. of Ophthalmol., Yayoi Hosp. pp.1001-1005
Published Date 1984/9/15
DOI https://doi.org/10.11477/mf.1410209253
  • Abstract
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We evaluated the possible efficacy of cefmenoxime (CMX), a new antibiotic, when used as 0.5% and 1.0% ophthalmic solutions.

In the rabbit eye, the concentration of CMX in the cul-de-sac showed a rapid decay either after a single instillation or five consecutive instillations at 5-minute intervals. A high concentration in the cul-de-sac was achieved with an additional use of soft contact lens for either method of instillation.

CMX showed a peculiarly good and persistent penetration into the cornea following instillation into the cul-de-sac.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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