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Significance of ophthalmological screening before systemic treatment with hydroxychloroquine for systemic lupus erythematosus Reina Saito 1,2 , Naoto Yokogawa 3 , Yukio Yoshino 4 , Tomomi Ogawa 5 , Akiko Ohno-Tanaka 2 1Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University 2Department of Ophthalmology, Tokyo Metropolitan Tama Medical Center 3Department of Rheumatology, Tokyo Metropolitan Tama Medical Center 4Nishikoku Eye Clinic 5Ogawa Eye Clinic pp.225-230
Published Date 2020/2/15
DOI https://doi.org/10.11477/mf.1410213476
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Abstract Purpose:To the outcome of ophthalmological screening before start of systemic treatment with hydroxychloroquine(HCQ)for systemic lupus erythematosus(SLE).

Cases and Method:This study was made on 210 SLE patients seen at the Tokyo Metropolitan Tama Medical Center during 86 months through March 2017. The series comprised 16 males and 194 females. Electronic medical records were retrospectively evaluated regarding age, sex, body weight and height, intended HCQ dosage, adjuvant therapy, visual acuity, intraocular pressure, fundus findings, slit-lamp microscopic findings, optical coherence tomographic findings, visual field and color vision test findings.

Results:Out of 210 cases, HCQ treatment was started in 197 cases(93.8%)and not in 13 cases(6.2%). Out of these 13 cases, HCQ was withheld in 5 cases due to ophthalmologically abnormal findings and in 8 cases due to systemic causes including pregnancy. SLE retinopathy was present in 3 cases and received systemic HCQ.

Conclusion:Systemic treatment with HCQ was initiated in 93.8% of cases of SLE after ophthalmological screening.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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