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Four cases of childhood-onset myasthenia gravis with onset at the age of five years or earlier Junko Matsuo 1 , Jun Sugasawa 1 , Yuko Nishikawa 1 , Masahiro Tonari 1 , Takashi Okuno 2 , Hidehiro Oku 1 , Tsunehiko Ikeda 1 , Hiroshi Tamai 3 1Department of Ophthalmology, Osaka Medical College 2Department of Ophthalmology, Korigaoka-Yukeikai Hospital 3Department of Pediatrics, Osaka Medical College pp.1245-1249
Published Date 2016/8/15
DOI https://doi.org/10.11477/mf.1410211911
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Abstract Purpose: To report 4 cases of childhood-onset myasthenia gravis.

Cases: All were females and were aged 14 months, 16 months, 3 years 2 months, and 5 years 10 months respectively at the time of initial visit.

Findings and Clinical Course: All the 4 cases showed blepharoptosis with diurnal variations. All were positive for tensilon test and were diagnosed with myasthenia gravis. All were classified as Class Ⅰ according to MGFA classification. All the cases were initially treated by systemic anticholinestrase, resulting in remission in one case. The other 3 cases achieved cure after systemic corticosteroid and tacrolimus. One case developed amblyopia following unilateral blepharoptosis lasting for 4 months.

Conclusion: Blepharoptosis or heterotropia may be initial signs of childhood myasthenia gravis. Persistent blepharoptosis may result in amblyopia.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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