Rinsho Ganka Volume 64, Issue 12 (November 2010)

Effect of systemic kallidinogenase on electroretinograms of patients with simple diabetic retinopathy Takayuki Terui 1 , Mineo Kondo 1 , Tadasu Sugita 1 , Shinji Ueno 1 , Hiroko Terasaki 1 1Dept of Ophthalmol,Nagoya Univ Grad Sch of Med pp.1917-1920
Published Date 2010/11/15
DOI https://doi.org/10.11477/mf.1410103473
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Abstract. Background:Electroretinogram(ERG)in eyes with diabetic retinopathy has shown prolonged implicit time of oscillatory potentials. Purpose:To report changes in ERG after peroral administration of kallidinogenase in eyes with simple diabetic retinopathy. Objects and Method:This prospective study was made on 32 eyes of 32 diabetic patients with HbA1c level of less than 10.0%. Seventeen cases were given kallidinogenase at the daily dosis of 150 units for 6 months. The other 15 cases served as control. All the cases were evaluated by full-field ERG before and after 6 months and were analyzed for a-wave,b-wave,and oscillatory potentials(O1 to O3). Results:The treated group showed significantly shortened implicit time of a-wave and O2. There were no changes in ERG in the control group. Conclusion:Peroral kallidinogenase resulted in shortened implicit times of some ERG components.

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64巻12号 (2010年11月)
電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院