IFN治療中に黄斑部漿液性網膜剝離を生じた2例

Two cases of serous retinal detachment in the macula following systemic treatment with interferon

要約　目的：慢性C型肝炎に対するインターフェロン（IFN）治療中に，黄斑部に漿液性網膜剝離が生じた2症例の報告。症例：1例は56歳男性，他の1例は41歳男性で，1例はIFN 2剤併用，他の1例は3剤併用による治療を受けていた。1例は投与49日目に左眼，6日後に右眼に漿液性網膜剝離が生じ，光干渉断層計（OCT）でこれに相当する所見があった。IFNを中止し，5週後に寛解した。他の1例はIFN開始から61日目に両眼の視力が低下し，黄斑部に漿液性網膜剝離があり，OCTでこれに相当する所見があった。治療を中止し，4週後に寛解した。両症例とも，蛍光眼底造影で蛍光漏出はなかった。結論：IFNの全身投与が黄斑部の漿液性網膜剝離の誘因であったと推定される。両症例とも，IFNの投与中止で寛解した。

Abstract.　Purpose：To report serous retinal detachment in the macula in 2 cases following systemic treatment with interferon for chronic hepatitis C. Cases：Both were males aged 56 and 41 yeas respectively. One case received two medications and the other received three medications including interferon for chronic hepatitis C. One case developed serous macular detachment in the left eye on day 49 of medication, followed by involvement of the fellow eye 6 days later. Optical coherence tomography（OCT）showed findings supporting the diagnosis. Discontinuation of interferon was followed by resolution 5 weeks later. The other case showed serous macular detachment in both eyes on day 61 of treatment with interferon. OCT showed findings supporting the diagnosis. Discontinuation of interferon was followed by resolution 4 weeks later. Both cases showed no dye leakage by fluorescein angiography. Conclusion：Systemic interferon is interpreted as the cause of observed serous macular detachment. Discontinuation of interferon was followed by spontaneous resolution in both cases.