新潟大学眼感染症クリニックにおける検出菌（1980年〜1984年）

Incidence of microorganisms isolated from ocular infections at Niigata University Eye Clinic from 1980 to 1984

　1980年より1984年に新潟大学眼感染症クリニックを受診した愚者1,448名を対象として，菌の検出ならびに主要検出菌の薬剤感受性を検査した．その結果以下のような成績が得られた．

（1）2,009株が分離され，Gram陽性球菌が1,120株（55.7％），Gram陰性桿菌が389株（19.4％）であった．Staphylococcus epidermidisが最も多く検出されGram陽性球菌の63.3％を占めた．Gram陰性桿菌では非発酵菌が52.7％と最多であった．

（2）薬剤耐性では，PCG耐性Staphylococcus aureusが毎年高頻度に見られたがMCIPC耐性株も1983年より出現した．MCIPC耐性のS．epider-midisは近年増加傾向にある．Pseudomonas aer-uginosaはABPC,CEPsに高度耐性株が多いが，GMやCLに耐性の株も出現してきた．非発酵菌ではDOXY耐性株が1984年より出現し，GM耐性株も増加してきている．これらの動向をふまえて，今後の眼感染症化学療法を考えていく必要がある．

We evaluated the incidence and drug sensitivity of microorganisms isolated from eye infections in 1,448 patients in our department over a 5 year period (1980-84). Out of a total of 2,009 strains of microorganisms isolated, 1,120 (55.7 %) were Gram-positive cocci and 389 (19.4 %) were Gram-negative rods. Staphylococcus epidermidis was the most frequent with 709 strains or 63.3 % of gram-positive cocci. Among Gram-negative rods, glucose non-fermentative ones were most fre-quently isolated (52.7%), followed by Haemophilus influenzae (16.2%), Pseudomonas aeruginosa (11.1%) and others. Anaerobic bacteria were also frequent (18. 5%).

The drug sensitivity of microorganisms were mea-sured by the disc method. Strains of Staphylococcus aureus showed high resistance to penicillin G through-out each year of the period. Strains resistant to cloxacil-lin appeared from 1983 on. There was a gradual rise in the frequency of strains of Staphylococcus epidermidisresistant to cloxacillin. Strains of Pseudomonas aer-uginosa showed very high resistance to ABPC and cephalosporins as well as occasional resistance to gentamicin and colistin. Doxycycline-resistant strains of glucose non-fermentative Gram-negative rods appeared in 1984. Gentamicin-resistant strains were on gradual increase during the period.

Rinsho Ganka (Jpn J Clin Ophthalmol) 40(3) : 233-238, 1986