老人性白内障の分類とその生化学的背景について

The clinical classification and biochemical back-ground in the senile cataracts

緒　言

　老人性内障の臨床的形態学について，古来から幾つかの報告があるが，Bellows^1）らによる分類は次の5種類に分けられている。つまり，

（1）　cortical

We quantitated the chemical constituents in surgically removed lenses due to senile cataract and compared the findings with the clinical type of cataracts. Measurements were made on sodium, potassium, calcium, magnesium, copper, iron and zinc concentrations. The amount of lens protein was determined by SDS gradient (PAGE) method.

Nuclear cataracts showed normal values for each item. Cortical cataracts, on the other hand, showed significantly raised Na⁺ and lowered K⁺ concentra-tion. The Na⁺/K⁺ ratio was reversed when com-pared with the normal values.