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はじめに
われわれはIDU点眼液をウサギに点眼すると,ウサギに奇形が発生することを知り,すでに予報の形で発表した1)。この論文はその詳細およびIDUに似た抗ビールス剤,F3TDR (trifluo—rothymidine)の催奇実験の結果を報告する。
Teratogenicities of antiviral ophthalmics such as IDU (5-iodo-2'-deoxyuridine 1mg/ml and thi-merosal 0.02 mg/ml) and F3TDR (trifluorothy-midine 10 mg/ml) have been evaluated on rab-bits (Japan albino) and rats (Wister).
Pregnant rabbits wers divided into 5 groups. All groups received O.1ml of antiviral ophthal-mic or control solution 4 to 6 times a day via conjunctival sac on days 6 through 18 of gesta-tion. Pregnant rats were divided into 3 groups and each group received 0.2ml of antiviral oph-thalmic or physiological saline by subcutaneous injection every day on days 6 through 18 of gestation.
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