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臨床的には,肝障害などの診断に用いられ,GOTは,筋>肝>骨格筋,脳に活性がつよく,血清に極めて少い。GPTは,肝に極めて多く,下つて心筋,骨格筋と多く,骨にも高いが血清には少い。血清と臓器の存在量の大きな差は診断上,有用とされる所由であり,GOTが心筋検査,ビィールス肝炎にGPTが同様,これらにつよく,中毒肝炎にも亢進がみられる。
Karmen等の紫外部吸収法(還元型MADの340mμの吸収減少の測定),Reitman-Frankelの比色法等がKitとしてある。
1) In diabetics, most cases show normal valueof GOT and GPT (67% and 76%), while 37% of the cases shows hyper-GPT and 21% only 4 to 3 % shows lower levels.
(2) The increase of GOT is observed rema-rkably in the seventies of age (66%) and scarcely in the forties, and is also observed in 28%~39% in other age groups. The incre-ase of GPT is dominant in the thirties (40 %) and is found in about to 30% in other age groups.
(3) The increase or decrease of GOT shows no difference between retinopathics and non-retinopathics, while the increase of GPT is observed more frequently in non-retinopathics than in retinopathics.
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