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Changes in intraocular pressure after switching from fixed combination of dorzolamide/timolol to brinzolamide and timolol Itsuo Watanabe 1 , Ichiro Watanabe 2 , Yoshiaki Ieki 2 1Shirai Hosp 2Dept of Ophthalmol, Kawasaki Med Sch pp.1171-1175
Published Date 2014/8/15
DOI https://doi.org/10.11477/mf.1410105346
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Abstract. Purpose:To report changes in intraocular pressure(IOP)after switching from fixed combination of dorzolamide/timolol to concomitant instillation of 1% brinzolamide and 0.5% timolol. Cases and Method:This retrospective study was made on 27 eyes of 15 patients with normal-tension glaucoma. The series comprised 3 males and 12 females. The age averaged 72.8±8.5 years. All the cases reported irritation after instillation of dorzolamide/timolol. The treatment was switched to brinzolamide and timolol. Patients were followed up for 6 months after switching regarding IOP and adherence to treatment. IOP averaged 13.9±1.9 mmHg in the series. Results:Averaged value of IOP decreased significantly for every months until 6 months after switching(p<0.05). The patients showed excellent adherence to treatment in spite of increased medications. Conclusion:Patients' adherence and decreased irritation are important factors in the treatment of glaucoma. Switching of medication also resulted in more ocular hypotension.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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