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Adherence to ocular hypotensive delivery system Hiroshi Kobayashi 1 1Dept of Ophthalmol, Kanmon Med Cent NHO pp.1127-1132
Published Date 2014/8/15
DOI https://doi.org/10.11477/mf.1410105338
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Abstract. Purpose:To study adherence of use of an ocular hypotensive delivery device for glaucoma drugs and the relationship between its adherence and age, gender, best-corrected visual acuity or visual filed. Methods:One hundred and ten patients who had been administered with latanoprost 0.04%(Xalatan®)or fixed combination latanoprost 0.04%/timolol 0.5%(Xalacom®)and who had had difficulty in eyedropping were enrolled. There were 35 men and 75 women and mean age was 74.8±11.7 years. An ocular hypotensive delivery device(Xal-Ease®)was given to the patients and their adherence of its use was studied for 6 months. Results:One hundred four patients(94.5%)completed the study. The rate of patients with good adherence with hypotensive delivery device use was 57.7% at 2 months, 69.2% at 4 months and 75.0% at 6 months(p<0.01). The rate in female patients between 60 and 74 years was 56.7%, which was significantly lower compared with the other patients(p<0.01). The duration between the acquisition of the device and the start of its use was 5.7±9.8 days in patients of younger than 60 years, 16.6±21.0 days in those between 60 and 74 years, and 22.3±31.9 days in those of 75 years or older;there was a significant correlation(p<0.01). Adherence with topical drug administration significantly improved in patients with good adherence with the device use(p=0.0005), whereas no significant difference was noted in patients with poor adherence(p=0.2). Conclusion:A relatively high percentage of patients used an ocular hypotensive delivery device, although female patients between 60 and 74 years used it significantly less compared with the other patients. There may be a learning curve, which may become steeper with age. Therefore, the ocular hypotensive delivery device should be improved to use more easily.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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