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Instillation of mitomycin C was effective in a case of keratoconjunctival carcinoma in situ Ai Izutani 1 , Yuka Okada 2 , Shizuya Saika 2 1Dept of Ophthalmol, Wakayama Med Univ Kihoku Hosp 2Dept of Ophthalmol, Wakayama Med Univ Sch of Med pp.979-982
Published Date 2014/7/15
DOI https://doi.org/10.11477/mf.1410105304
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Abstract. Purpose:To report a case of keratoconjunctival carcinoma in situ that resolved after instillation of mitomycin C. Case:A 57-year-old male presented with corneal opacity since 3 years before. He had atopic dermatitis and had received cataract surgery in the right eye 10 years before. Findings:Corrected visual acuity was 0.5 right and 1.0 left. The right eye showed corneal opacity with invasion of conjunctiva. The lesion was diagnosed with keratoconjunctival carcinoma in situ by biopsy. The right eye was treated by topical instillation of 0.02% mitomycin C four times daily. The corneal opacity started to regress. Biopsy 2 months later showed epithelial dysplasia. Biopsy after 3 months of further treatment showed no sign of malignancy leading to discontinuation of instillation. There has been no recurrence or corneal epithelial lesion for 11 months until present. Conclusion:Instillation of mitomycin C was effective for keratoconjunctival carcinoma in situ.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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