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要約 目的:HIV関連網膜微小血管症とHIV脳症の関連について検討する。対象と方法:2000~2009年の間に都立駒込病院において抗HIV治療の開始時に眼科を受診した383例を対象とし,HIV関連網膜微小血管症の有無とHIV脳症の有無を後方視的に調査し,2つの疾患の関連を検討した。結果:HIV関連網膜微小血管症は85例,HIV脳症は9例でみられた。2つの疾患の間には有意な関連があった(p=0.0013,Fisherの正確確率検定)。結論:HIV関連網膜微小血管症が存在する症例ではHIV脳症の合併頻度が高い。HIV関連網膜微小血管症は,HIV脳症合併の危険因子である可能性がある。
Abstract. Purpose:To investigate the association between HIV-related retinal microangiopathy and HIV associated neurocognitive disorders(HAND). Methods:Single-center, cross-sectional, retrospective study. Study participants were 383 HIV-infected patients who were assessed for ocular manifestations before the beginning of antiretroviral therapy. The presence of HIV-related retinal microangiopathy and HAND were collected from the medical records. The significance of association between HIV-related retinal microangiopathy and HAND was determined by Fisher's exact test. Results:HIV-related retinal microangiopathy was present in 85 patients, and HAND was present in 9 patients. There was a significant association between presence of HIV-related retinal microangiopathy and presence of HAND(p=0.0013:Fisher's exact test). Conclusions:This finding indicates that patients who have HIV-related retinal microangiopathy tend to complicate HAND. Thus, the presence of HIV-related retinal microangiopathy may be a predictive factor for concomitance of HAND.
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