眼科用薬剤感受性プレートの臨床的有用性

Clinical usefulness of ophthalmic antimicrobial susceptibility plate

要約　目的：新しい眼科用薬剤感受性測定オーダープレート（SG07）の臨床的評価。対象と方法：国内の5施設で眼感染症と診断された患者82例から分離された98株を対象とした。細菌培養と同定，および薬剤感受性を5施設それぞれの方法で実施した。得られたすべての菌株の薬剤感受性を阪大微生物病研究会でSG07により判定した。64症例で薬剤感受性と治療効果を比較した。結果：2施設で11株についてSG07により調べた11薬剤への感受性は84.3％で一致した。治療薬の感受性を測定できたのは，各施設で32.8％，SG07で95.3％であった。67.2％の症例で各施設での判定よりもSG07が優れていた。結論：新しい眼科用薬剤感受性測定オーダープレート（SG07）により，主要抗菌点眼薬の薬剤感受性を測定できた。これは眼感染症の治療に有用である。

Abstract.　Purpose：To report the outcome of clinical evaluation of SG07,an ophthalmic antimicrobial susceptibility plate which was newly developed to quantitate the minimum inhibitory concentration（MIC）for bacterial isolates in ocular infection. Cases and Method：This study was made on 98 bacterial strains isolated from 82 patients in 5 institutions. Each institution conducted bacterial culture and identification. All the isolated strains were sent to a center for reevaluation including the use of SG07. A total of 64 strains were tested for drug sensitivity and clinical effect. Results：Eleven strains were evaluated regarding sensitivity to 11 antimicrobial drugs in two institutions. There was a concordance in 84.3％. Drug sensitivity was possible in 32.8％ of strains when tested by each of 5 institutions using conventional methods and in 95.3％ by SG07. Findings by SG07 served as a better clinical guideline than by routine methods in 43 patients（67.2％）. Conclusion：It was possible to quantitate MIC of bacterial isolates from ocular infection by using SG07. SG07 promises to be useful in the treatment of ocular infections.