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要約 目的:網膜中心静脈閉塞症に対する組織プラスミノゲン活性化因子硝子体投与の至適使用量の検討。対象と方法:矯正視力が0.5未満の網膜中心静脈閉塞症37眼を対象とし,溶解後5分以内の組織プラスミノゲン活性化因子を硝子体に注入した。最初の18眼には4万単位,次の19眼には2万単位を用いた。結果:術前視力と比較し,4万単位群では術後6か月の視力が有意に改善し(p=0.018),2万単位群では有意な改善がなかった(p=0.51)。結論:網膜中心静脈閉塞症に対して組織プラスミノゲン活性化因子を硝子体に投与した。4万単位投与では6か月後の視力が有意に改善し,2万単位では改善しなかった。
Abstract. Purpose:To report the efficacy of intravitreally administered tissue plasminogen activator for central retinal vein occlusion(CRVO). Case and Method:This study was made on 37 eyes diagnosed with CRVO. Initial 18 eyes received intravitreal injection of 40,000 units and the next 19 eyes received 20,000 units of tissue plasminogen activator which was dissolved within 5 minutes before using. Results:When compared with initial visual acuity,visual acuity significantly improved in the group that received 40,000 units after 6 months(p=0.018). There was no change in visual acuity in the group that received 20,000 units(p=0.51). Conclusion:Tissue plasminogen activator was intravitreally administered in 37 eyes of CRVO. Visual acuity improved 6 months after injection of 40,000 units and not after injection of 20,000 units.
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