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Optimal intravitreal dosis of tissue plasminogen activator for central retinal vein occlusion Takaya Miyawaki 1,2 , Shigeo Yaguchi 3 , Tadahiko Kozawa 1 , Toshiyuki Kawahara 1 1Kozawa Eye Hosp and Diabet Cent 2Miyawaki Eye Clin 3Dept of Ophthalmol,Showa Univ Fujigaoka Rehab Hosp pp.1051-1056
Published Date 2011/7/15
DOI https://doi.org/10.11477/mf.1410103739
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Abstract. Purpose:To report the efficacy of intravitreally administered tissue plasminogen activator for central retinal vein occlusion(CRVO). Case and Method:This study was made on 37 eyes diagnosed with CRVO. Initial 18 eyes received intravitreal injection of 40,000 units and the next 19 eyes received 20,000 units of tissue plasminogen activator which was dissolved within 5 minutes before using. Results:When compared with initial visual acuity,visual acuity significantly improved in the group that received 40,000 units after 6 months(p=0.018). There was no change in visual acuity in the group that received 20,000 units(p=0.51). Conclusion:Tissue plasminogen activator was intravitreally administered in 37 eyes of CRVO. Visual acuity improved 6 months after injection of 40,000 units and not after injection of 20,000 units.


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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