Instillation of autologous serum was effective in two cases of corneal disorders secondary to anticancer drug TS-1® Kozo Katsumura 1 , Ryousuke Ochi 1,2 , Ryousuke Koumoto 1,3 , Masako Hattori 1 , Kazuhiro Shimizu 1 , Bunpei Sato 1,3 , Tsunehiko Ikeda 1 1Dept of Ophthalmol,Osaka Med Coll 2Dept of Ophthalmol,Yodogawa Christian Hosp 3Dept of Ophthalmol,Osaka Kasiei Hosp pp.363-367
Published Date 2011/3/15
DOI https://doi.org/10.11477/mf.1410103585
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Abstract. Purpose:To report two cases who developed corneal disorders after treatment with peroral anticancer drug,TS-1®,following surgery for gastric cancer and who showed improved corneal disorders after topical treatment with autologous serum. Cases and Findings:Both were males aged 81 and 82 respectively. Both had received surgery for gastric cancer and had been treated with peroral TS-1®for about one year each. Convoluted subepithelial opacity was present in the cornea in both cases. The opacity persisted in both cases after discontinuation of TS-1®and treatment with conventional topical medications. Instillation of 20% autologous serum 6 times daily resulted in improved corneal findings with partial improvement of visual acuity. Conclusion:Instillation of autologous serum was followed by improved corneal disorders that developed after prolonged systemic treatment with TS-1®.

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