角膜新生血管に対しベバシズマブ点眼が有効であった1例

Instillation of bevacizumab was effective in a case of corneal neovascularization

要約　目的：角膜新生血管に対しベバシズマブ点眼が奏効した一例の報告。症例：59歳女性が左眼の眼痛で受診した。2年前からドライアイとして加療中であった。所見：矯正視力は左右とも1.2であり，左眼に角膜変性と血管侵入がある淡黄色の角膜混濁があった。ベタメタゾン点眼で角膜混濁が拡大した。1％ベバシズマブの点眼2か月で新生血管が退縮した。3週間後に新生血管が再発し，点眼を再開した。1週間後に新生血管が小さくなり，2か月後に退縮した。結論：ステロイド点眼に反応しない角膜新生血管に対し，ベバシズマブ点眼が有効であった。

Abstract.　Purpose：To report a case in whom instillation of bevacizumab was effective for corneal neovascularization. Case：A 59-year-old woman presented with pain in the left eye. She had been treated for dry eye during the foregoing 2 years. Finding：Corrected visual acuity was 1.2 in either eye. The left eye showed corneal degeneration and yellowish opacity with neovascularization. Corneal opacity enlarged following instillation of betamethasone. Instillation of 1％ bevacizumab for 2 months was followed by recession of corneal opacity. Corneal neovascularization recurred 3 weeks later. Instillation of bevacizumab was followed by recession of neovascularization one week later and by disappearance 2 months later. Conclusion：Topical bevacizumab was effective for corneal neovascularization resistant to topical corticosteroid.