Radiological Evaluation of the Response to Chemotherapy for Osteosarcoma Shinji MIWA 1 , Junichi TAKI 2 , Norio YAMAMOTO 1 , Toshiharu SHIRAI 1 , Hideji NISHIDA 1 , Katsuhiro HAYASHI 1 , Akihiko TAKEUCHI 1 , Hiroaki KIMURA 1 , Kentaro IGARASHI 1 , Akishi OOI 3 , Hiroyuki TSUCHIYA 1 1Department of Orthopaedic Surgery,Kanazawa University Graduate School of Medical Science 2Department of Biotracer Medicine,Kanazawa University Graduate School of Medical Science 3Department of Molecular and Cellular Pathology,Kanazawa University Graduate School of Medical Science Keyword: 骨肉腫(osteosarcoma) , 化学療法(chemotherapy) , 画像評価(radiological evaluation) pp.689-695
Published Date 2011/8/25
DOI https://doi.org/10.11477/mf.1408102061
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 Sixty-one patients with osteosarcoma were examined by radiographs,angiograms,MRI,201Tl and 99mTc-MIBI scintigram to evaluate their response to preoperative chemotherapy. All patients were classified as either responders or non-responder according based on the imaging findings. The radiographs were evaluated according to the degree of sclerotic change and cortical recovery,and the angiograms were evaluated according to the degree of vascular change. MR images were evaluated according to the rate of extraskeletal mass reduction. The 201Tl and 99mTc-MIBI scans were evaluated by the percentage reduction of the uptake ratio. All patients were evaluated on the basis of a pathological examination of the resected specimens. We also devised a combined radiological scoring system according to the predictive power of each type of diagnostic image and investigated the correlation between the radiological evaluation and the pathological evaluation. Sensitivity,specificity,and accuracy were 81.0%,19.0%,and 60.3%,respectively for the radiographs;77.1%,20.0%,and 60.0%,respectively,for angiograms;82.1%,69.0%,and 75.4%,respectively for MRI;81.5%,68.0%,and 75.0%,respectively,for 201Tl scans;76.7%,70.6%,and 74.5% for 99mTc-MIBI scans;and 88.9%,84.0%,and 86.9%,respectively,for the combined radiological evaluation.

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