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Use of 99mTc-MIBI Scintigram in the Evaluation of the Response of Chemotherapy to Malignant Bone and Soft Tissue Tumor. ; Comparison with 201Tl Scintigram and Angiogram Shinji Miwa 1 , Hiroyuki Tsuchiya 1 , Toshiharu Shirai 1 , Katsuhiro Hayashi 1 , Issei Onari 1 , Katsuro Tomita 1 , Junichi Taki 2 1Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Science 2Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Science Keyword: 99mTc-MIBIシンチグラム , 99mTc-MIBI scintigram , 悪性骨軟部腫瘍 , malignant bone and soft tissue tumor , 化学療法 , chemotherapy pp.157-163
Published Date 2010/2/25
DOI https://doi.org/10.11477/mf.1408101680
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 All 64 patients with malignant bone or soft tissue tumors who were the subjects of this study were examined by 99mTc-MIBI scintigram, 201Tl scintigram, and angiography to evaluate their response to chemotherapy. The percentage reductions in uptake ratios and the changes vascularity assessed by angiography were compared with histological assessments. Based on the angiographic findings the results were assessed as CR (complete response), PR (partial response), NC (no change), or PD (progressive disease). On the images, 99mTc-MIBI≧25%, 201Tl≧30%, and CR/PR in the angiograms were assessed as responders. All tumors were surgically resected, and the therapeutic effect was assessed by histopathological examination of the resected specimen. The tumors of poor responders showed less than 90% necrosis, and the tumors of good responders showed 90% or more necrosis. Sensitivity, specificity, and accuracy were 86.7%, 91.2%, and 89.1%, respectively, for 99mTc-MIBI imaging, 80.0%, 70.6%, and 75.0%, respectively for 201Tl imaging, and 86.7%, 38.2%, and 60.9%, respectively for angiography. The results of this study showed that 99mTc-MIBI scintigram could be effectively used to predict the final response of malignant bone and soft tissue tumors to chemotherapy.


Copyright © 2010, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1286 印刷版ISSN 0557-0433 医学書院

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