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IMMUNOHISTOCHEMICAL STUDY OF PLACENTAL FORM OF GLUTATHIONE S-TRANSFERASE IN HUMAN BRAIN TUMORS AND FETAL BRAINS Mitsutoshi Nakamura 1 , Shigeru Tsunoda 1 , Yasuharu Watabe 1 , Takahide Shimomura 1 , Toshisuke Sakaki 1 , Noboru Konishi 2 , Yoshio Hiasa 3 1Department of Neurosurgery, Nara Medical University 2Department of 1st Department of of Pathology, Nara Medical University 3Department of 2nd Department of Pathology, Nara Medical University Keyword: brain tumor , fetal brain , GST—π pp.965-970
Published Date 1990/10/1
DOI https://doi.org/10.11477/mf.1406900111
  • Abstract
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The activity of glutathione S-transferase placen-tal form (GST-π) was examined in 100 cases in-cluding various histologic subtypes and grading of human brain tumors and 10 cases of fetal brains by immunohistochemical studies.

The 69% of cases with brain tumors were shown to be positive for GST-π. This activity in neuro-epithelial tumors tended to increase in order to tumor grading, however, medulloblastoma and primi-tive neuroectodermal tumor (PNET) were not immunoreactive with GST-π. Embryonal car-cinoma showed strong staining, although fetal brains were negative. The metastatic braintumors showed the same reactivity with GST-π as those of original carcinomas. Moreover, the differenceof GST-π activity was investigated on some brain tumors treated with or without antitumor drug, such as 1-(4-amino-2-methyl-5-pyrimidiny) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (AC-NU). The 85% of recurrent cases showed strong staining with GST-π, and GST-π activity seemed to be incresed after treated with ACNU.

The present study indicated that GST-π might be a useful marker for human brain tumor, as the same conclusion was applicable to other neo-plastic lesions examined previously.

It is suggested that the increased GST-π activity with malignancy of tumor may indicate the ten-dency to recurrence. The presence of such activity in tumor cells may also imply their acquired mul-tidrug resistance. Our findings suggest that the evaluation of GST-π activity in brain tumors will offer a predictive value for eventual behavior of the tumor.


Copyright © 1990, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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