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CHANGES IN CONTENT OF EXCITATORY AMINO ACIDS IN THE BRAIN AND CEREBROSPINAL FLUID Hiroyuki Nakatsu 1 , Takaoki Tada 1 , Takahiko Eguchi 1 , Hidehiro Hirabayashi 1 , Toshisuke Sakaki 1 , Yasuyoshi Enoki 2 1Department of Neurosurgery, Nara Medical University 2Second Department of Physiology, Nara Medical University Keyword: epilepsy , kindling , glutamate , aspartate pp.971-977
Published Date 1990/10/1
DOI https://doi.org/10.11477/mf.1406900112
  • Abstract
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Recently epilepsy is analysed on terms of two different conditions, seizure susceptibility and seizure induction. Much attention has been paid to excitatory amino acids in these conditions. An examination was made of changes of glutamate and aspartate in the brain and cerebrospinal fluid (CSF) in a cat amygdaloid kindling model so as to determine whether excitatory amino acids arepossibly involved in seizure susceptibility and seizure induction.

Twenty crossbred adult cats were divided into four groups : a sham operation group (Sh) as the control, just after stage 4 seizure group (S4), just after stage 6 seizure group (S6), and stage 6 group 2 weeks after the last stimulation (S6-2W). CSF, blood and 13 individual brain regions were taken at 9+4℃, and their glutamate and aspartate contents were meansured by high performance liquid chromatography (HPLC).

Glutamate concentration was significantly higher in the S6 group than in the Sh group in CSF and less in the S6 group than in the Sh group in the left and right amygdala, hippocampus and piriform cortex. No aspartate could be detected in the CSF of any group, nor did it change signi-ficantly in the blood or brain.

Based on the above results, the content and release of glutamate and aspartate apparently do not change in seizure susceptibility and glutamate is released from kindled tissues in seizure induc-tion, thus showing it to be involved in seizure induction in a cat amygdaloid kindling.


Copyright © 1990, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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