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Brain and Nerve No to Shinkei Volume 16, Issue 8 （August 1964）

Brain and Nerve 脳と神経 16巻8号（1964年8月発行）

Japanese English

研究

てんかん賦活脳波にみられるseizure dischargeの特異性 MODE OF EPILEPTIC SEIZURE DISCHARGE IN ACTIVATED EEG, ESPECIALLY ON ITS SPECIFIC CHARACTER 鷲塚昌一 ¹ Shoichi WASHIZUKA ¹ ¹弘前大学医学部神経精神科 ¹Dept. of Neuropsychiatry, Hirosaki Univ. School of Med. pp.646-652

発行日 1964年8月1日 Published Date 1964/8/1

DOI https://doi.org/10.11477/mf.1406206455

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Abstract 文献概要
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I．緒言

　今日，脳波上，てんかんはcerebral paroxysmal dysrhythmiaとよばれているが，賦活の結果みられるparoxysmal dischargeのあるものがてんかん以外の疾患でも^3）4），また時には正常者においてさえも認められることはけつして珍しくはないし^1）2）3），従つてまたそのてんかん特異性について多くの疑義も述べられている^5）。

　このように，賦活によつて誘発されたparoxysmal dischargeが，とくにてんかんのみに特異的な反応ではないとすれば，どのようなpatternがどの程度にてんかんならびに非てんかんに認められるか——それを検討した上で，逆にてんかん異常波の診断価値を確かめることが必要であろう。

One hundred and seventy cases of untreated patients diagnosed clinically as definite epilepsy were studied, and 170 cases of neurosis and 170 cases of sequelae of head injury were used as controls in this study.

As to seizure discharges introduced by metrazol-megimide or MM activation (Wada et al), especially non-rhythmic spike-and-wave complex (SP-W-C) and high voltage slow wave (HVS) in question, the author studied whether or not the mode of seizure discharges has any differences between epileptics and non-epileptics. The results obtained are as follows.

1) Many spike and SP-W-C are found in seizure discharges in epilepsy, and among them the type III which has many spikes is characteristic in the epilep-tic EEG.

2) Also in the duration of burst of seizure dis-charges, epilepsy is characterized by the long-timed type which continues more than 3 minutes, because the longer the time is, the more the EEG has the element of spikes.

3) In epilepsy it is found that the bursts of seizure discharges under activation give various changes and are apt to change remarkably into the type containing many spikes.

4) The frequency of burst appearance has the highest value in many epilepsy within 5 minutes after activation; the frequency of burst appearance per minute is more than 3 times. On the contrary, non-epileptic group is generally once per minute, and the initial seizure discharge is later than 5 minutes.

5) The burst of seizure discharges in many cases of epilepsy appears continuously after injection more than 3 times per minute.

Difference between epileptics and non-epileptics is statistically significant.

6) As to the kind of the initial seizure discharge, spike and spike-and-wave complex in epilepsy, are found as high as 85%; these of sequelae of head injury 50% and these of neurosis 17%.

7) As to amplitude of seizure discharges found in the burst, many epileptics show more than 300μV, and the amplitude is statistically significant between epileptics and non-epileptics.