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Brain and Nerve No to Shinkei Volume 40, Issue 6 （June 1988）

Brain and Nerve 脳と神経 40巻6号（1988年6月発行）

Japanese English

原著

Gd-DTPA投与による脳腫瘍組織緩和時間の変化—T₁値経時推移とtissue-blood ratioの腫瘍種別による差異 CHANGES IN TISSUE T1 OF BRAIN TUMOR FOLLOWING GD-DTPA ADMINISTRATION: DIFFERENCES IN T1 TIME COURSE AND TISSUE-BLOOD RATIO BY HISTOLOGICAL TYPES 吉田和雄 ¹ , 古瀬和寛 ¹ , 金桶吉起 ² , 佐生勝義 ¹ , 茂木禧昌 ² Kazuo Yoshida ¹ , Masahiro Furuse ¹ , Yoshiki Kaneoke ² , Katsuyoshi Sasou ¹ , Yoshimasa Motegi ² ¹中津川市民病院脳神経外科 ²中津川市民病院神経内科 ¹Departments of Neurosurgery, Nakatsugawa Municipal General Hospital ²Departments of Neurology, Nakatsugawa Municipal General Hospital pp.531-537

発行日 1988年6月1日 Published Date 1988/6/1

DOI https://doi.org/10.11477/mf.1406206115

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Abstract 文献概要
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　抄録　Gd-DTPA没与による脳腫瘍組織，周囲浮腫脳ならびに健常組織のT₁値変化について検討した。対象は脳腫瘍患者10症例（髄膜腫4例，神経膠芽腫2例，転移性脳腫瘍3例，脳膿瘍1例）で，FONARQED 80-αを用いてT₁値をGd-DTPA静注直後から約1時間後まで繰返し計測した。また9症例においては，経時的に（静注前，静注後5分，10分，15分，30分，60分）採血をあわせておこなった。腫瘍組織においては静注後5分で最低T₁値となった後次第に回復していくが，全血R₁値変化と腫瘍R₁値変化からtissue-blood ratioを求め，5分後と30分後の比（TBR₃₀／TBR₅）を求めた結果，髄膜腫は1.0〜1.5，他の脳腫瘍は1.5〜3.0と腫瘍種別による相違が認められた。周囲浮腫脳においては1例を除き，健常組織においては全例で，有意なT₁値変化を認めなかった。以上のようにGd-DTPAによるT₁値の効果はBBB機能のindicatorとしても重要な役割を持つと考えられた。

Effect of Gd-DTPA on tissue T1 were studied in 10 patients with intracranial tumors, including 4 meningiomas, 2 gliomas, 3 metastatic tumors and 1 brain abscess. T1 values were compara-tively measured in the various portions of tumor tissue, peritumoral edema and normal brain before and after intravenous injection of 0.1 mmol Gd-DTPA per kg weight, with the time ranges be-tween 5 and 60 minutes. In vivo T1 was deter-mined by means of field focusing technique of a FONAR QED 80-alpha system (0.05 T). T1 values of blood sample were also seriously measured and applied to estimate the enhancement pattern in the varied tumors.

Meningiomas showed the maximal decrease of T1 5 minutes after Gd-DTPA administration and rapid recovery of T1 fairly paralleling to that of whole blood. On the other hand, such tumors as gliomas and metastasis revealed very slowly re-covery of T1 followed by the similar T1 decrease just after administration of Gd-DTPA. In the portions of peritumoral edema and normal brain, there were no significant changes in tissue T1 by Gd-DTPA adminitsration. In order to evaluate the clearance pattern of Gd-DTPA in tumor tissue, tissue-blood ratio (TBR) was calculated from the relaxation values at the terms of 5 and 30 minutes following Gd-DTPA administration. The ratios of relaxation rates, TBR 30/TBR 5, were ranged from 1.0 to 1.5 in cases of meningiomas, whereas they distributed in the ranges from 1.5 to 3.0 in the other types of brain tumors. This value ofTBR 30/TBR 5 convincingly depends upon the dif-ferences in histological types of tumors.

It is concluded that the concentration ratio of Gd-DTPA between blood and tissue may be theactual value related to nature of brain tumors, probably indicating the different attitudes of in-volvement in blood-brain barrier function.