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EFFECTS OF HALOTHANE AND ISOFLURANE ON THE CANINE DUODENAL PARANEURONS Kazunori Sato 1,3 , Ryoko Noguchi 1 , Kiichiro Taga 1 , Koki Shimoji 1 , Tsuneo Fujita 2 1Department of Anesthesiology, Niigata University, School of Medicine 2Department of Anatomy, Niigata University, School of Medicine pp.485-490
Published Date 1988/5/1
DOI https://doi.org/10.11477/mf.1406206108
  • Abstract
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Administration of amino acid solution (50 mM tryptophane and phenylalanine in saline) into the canine duodenum is known to cause an increase in pancreatic secretion. This response is mediated by the excitation of duodenal endocrine cells, paraneurons, which release cholecystokinin (CCK)into the systemic circulation in response to intra-luminal amino acid stimuli. Pancreatic secretory cells are then evoked by the CCK in the blood to secrete the juice into the duodenum. The authors investigated the effects of two general anesthetics, halothane and isoflurane, on this response. Nine mongrel dogs were subjected to this study. Each dog underwent laparotomy under nitrous oxide (75%) -oxygen (25%) anesthesia with pancuronium (GO-Pb). The duodenal loop was exposed and two polyethylene cannulae (18Fr) were introduced into the loop. Proximal cannula was for the admini-stration of the amino acid solution into the loop, and distal one was for drainage of the solution. The pancreatic duct was inserted with a polyethy-lene catheter, through which pancreatic juice was collected and measured for the volume and protein output by spectrophotometry. After these surgical procedures, the pancreatic secretory response to intraluminal amino acid stimuli was examined under GO-Pb (Control). Then halothane (1. 0%) (Group 1, four dogs) or isoflurane (2.0%) (Group 2, five dogs) was administered for 30 min and the same response was tested.

The pancreatic secretory response to intralumi-nal amino acid stimulus was suppressed by the surgical concentrations of both halothane (1.0%) and isoflurane (2.0%). Neither halothane nor isoflurane suppressed the pancreatic secretory response evoked by intravenous CCK infusion (10 Ivy Dog Units). The results indicate that both anesthetics affect the duodenal paraneurons which release CCK, but not the pancreatic cells respon-ding to the hormone. Thus, the study suggests that the suppressive effects of both anesthetics on the duodenal paraneurons must be considered for the management of patients who receive enteral nutrition during the perioperative period or in the intensive care unit and also for the examination of pancreatic secretory response under general anesthesia. Further, the present experimental arrangement might provide a simple model for investigation of anesthetic effects on the activities of neurons and transmitter release.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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