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EXPERIMENTAL HERPES SIMPLEX VIRUS ENCEPHALITIS:EFFECT OF ARA-A TREATMENT, AND SEROLOGICAL AND PATHOLOGICAL STUDY Takeshi Kurata 1 , Sugishi Ohtani 2 , Shigeru Fukushima 1 , Kozaburo Hayashi 1 , Atsuko Yamamoto 1 , Yuzo Aoyama 1 , Hirmichi Mizutani 3 1Department of Pathology Institute of Medical Science, University of Tokyo 2Department of Infectious Diseases, Institute of Medical Science, University of Tokyo 3Department of Virus Research, Kanto Teishin Hospital pp.913-920
Published Date 1983/9/1
DOI https://doi.org/10.11477/mf.1406205188
  • Abstract
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The effect of Ara-A treatment on the experi-mentally induced herpes simplex virus (HSV) ence-phalitis in rabbits was examined. Simultaneously practical value of enzyme-linked icnmunosorbent assay (ELISA) for rapid diagnosis was tested to find an early rise of antibody in cerebrospinal fluid (CSF) and serum in connection with an adop-tion of Ara-A administration. F-ISV encephalitis was produced by inoculation with type-1 HSV into the bilateral corneas of the eyes. A large amount of pus and typical neurological signs cha-racteristic to encephalitis appeared after several days of infection. Ara-A therapy begun at the 3rd day of infection clearly increased the survi-val rate (90%) and improved the clinical signs, but the start of the drug at the 6th day could only increase the survival rate (60%) without cure of the clinical symptoms. ELISA could catch the early rise of IgG antibody in CSF from 3-4 days and in serum from 4-6 days after infection. Ara-A didn't interfere the antibody production. Viral antigens were found in the corneal epithelia and propria, neurons and Schwann's cells of trigeminal ganglia, neurons and glial cells of pons and cereb-rum, especially in hippocampal nuclei. Typical Cowdry A and full type intranuclear inclusion bodies in the neurons were observed in the above tissues with infiltration of large amount of small round cells. In conclusion, Ara-A therapy in HSV encephalitis at the early stage of infection was quite effective for cure and the ELISA method is a useful tool for detection of early antibody rise in CSF and serum.


Copyright © 1983, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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